October 31, 2014

The correlation between the bronchial hyperresponsiveness to methacholine and asthma like symptoms by GINA questionnaires for the diagnosis of asthma

Research article

Open Access

So Yeon Lim1Young Joo Jo2 and Eun Mi Chun1*

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October 30, 2014

The effect of the novel phosphodiesterase-4 inhibitor MEM 1414 on the allergen induced responses in mild asthma

Research article

Open Access

Brian R LeakerDave SinghFerhana Y AliPeter J Barnes and Brian O´Connor

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Published: 28 October 2014

Positive serum specific IgE has a short half-life in patients with penicillin allergy and reversal does not always indicate tolerance


Open Access

Janni HjortlundCharlotte Gotthard MortzTore Bjerregaard StagePer Stahl SkovRonald Dahl and Carsten Bindslev-Jensen
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Expert roundtable on Sublingual Immunotherapy

Journal of Allergy and Clinical Immunology: In PracticeAmerican Academy of Allergy and Asthma and Immunology
Expert Roundtable on 
Sublingual Immunotherapy
Linda Cox, MD, FAAAAI • Thomas Casale, MD, FAAAAI • Peter Creticos, MD, FAAAAI • Stephen Durham, MA, MD, FRCP
Linda Cox, MD, Clinical Associate Professor, Nova Southeastern UniversityTom Casale, MD, Professor of Medicine, University of South Florida
Peter Creticos, MD, Associate Professor, Johns Hopkins School of MedicineStephen Durham, MD, Professor of Allergy and Respiratory Medicine, Imperial College London
View Web Conference
RELEASE DATE: September 15, 2014 • EXPIRATION DATE: September 15, 2016

Diagnosis and management of food allergies: new and emerging options: a systematic review

Authors Andrew W O'Keefe,1,2 Sarah De Schryver,1 Jennifer Mill,3 Christopher Mill,3 Alizee Dery,1 Moshe Ben-Shoshan1
Published Date October 2014 Volume 2014:7 Pages 141—164
Received 15 July 2014Accepted 19 August 2014, Published 24 October 2014
Approved for publication by Dr Linda Cox

SLIT: indications, follow-up, and management

I Dávila1, A Navarro2, J Domínguez-Ortega3, A Alonso4, D Antolín-Amérigo5, MC Diéguez6, E González-Mancebo7, C Martín8, C Martínez9, B Núñez10, N Prior11, M Reche12, A Rosado13, J Ruiz-Hornillos14, A Sansosti15, M Torrecillas16, MJ Jerez17; QUASAR Group (QUality in the Administration of SLIT in Allergic Rhinitis)

October 28, 2014

Histamine H4 receptor: A Novel Drug Target For Immunoregulation and Inflammation. Open Access Book

Aims and Scope

H4R is the newest member of the histamine receptor family, which was discovered about twelve years ago. It is considered a very promising drug target. The effort to improve the pharmacokinetic properties of the currently available H4R ligands is reflected in a steadily growing number of scientific publications and patent applications. Preclinical data strongly confirms the need for novel potent H4R ligands to explore their therapeutic value in allergy, inflammation, autoimmune disorders, and possibly, cancer.
Readers will be provided with extensive knowledge on histamine metabolism, as well as cellular histamine transport, storage and release, effects of histamine and histamine receptor ligands, with particular attention to the H4R, on inflammatory cells including mast cells, basophils, eosinophils, neutrophils, macrophages, dendritic cells, and T cells. The present knowledge on the regulatory role of histamine and the therapeutic exploitation of histamine receptor ligands in atopic diseases, with emphasis on human and animal models of asthma, allergic dermatitis and pruritus are discussed.

Developmental profiles of eczema, wheeze, and rhinitis: two population-based birth cohort studies

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