January 14, 2018

Reference values for spirometry in elderly individuals: a cross-sectional study of different reference equations

Open Access
  • Joana BeloEmail author,
  • Teresa Palmeiro,
  • Iolanda Caires,
  • Ana L. Papoila,
  • Marta Alves,
  • Pedro Carreiro-Martins,
  • Maria A. Botelho and
  • Nuno Neuparth
Multidisciplinary Respiratory Medicine201813:4
Abstract
Background
Spirometry is the single most important test for the evaluation of respiratory function. The results are interpreted by comparing measured data with predicted values previously obtained from a reference population. Reference equations for spirometry have been discussed previously.

January 13, 2018

The Diagnostic Accuracy of Fractional Exhaled Nitric Oxide Testing in Asthma: A Systematic Review and Meta-analyses

Audio/Video
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January 10, 2018

Effect of air quality alerts on human health: a regression discontinuity analysis in Toronto, Canada

Open Access
Hong Chen, Qiongsi Li, MMath, Jay S Kaufman, PhD, Jun Wang, MSc, Ray Copes, MD, Yushan Su, PhD, Tarik Benmarhnia, PhD

Summary
Background
Ambient air pollution is a major health risk globally. To reduce adverse health effects on days when air pollution is high, government agencies worldwide have implemented air quality alert programmes. Despite their widespread use, little is known about whether these programmes produce any observable public-health benefits. We assessed the effectiveness of such programmes using a quasi-experimental approach.

December 30, 2017

Recovery of hypothalamo–pituitary–adrenal axis suppression during treatment with inhaled corticosteroids for childhood asthma

Authors Gangadharan AMcCoy PPhyo A, McGuigan MP, Dharmaraj P, Ramakrishnan R, McNamara PS, Blair J
Published 15 December 2017 Journal of Asthma and Allergy Volume 2017:10 Pages 317—326
Objective: To describe recovery of adrenal insufficiency in asthmatic children treated with inhaled corticosteroids (ICS) and cortisol replacement therapy.

December 29, 2017

Case report: atypical presentation of vancomycin induced DRESS syndrome: a case report and review of the literature


Open Access
Open Peer Review
  • Olivia Wilcox,
  • Mohamed Hassanein,
  • John Armstrong and
  • Nader KassisEmail author
BMC Pulmonary MedicineBMC series – open, inclusive and trusted201717:217

Abstract
Background
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe hypersensitivity drug reaction involving the skin and multiple internal organ systems.

December 27, 2017

Immunosenescence in aging: between immune cells depletion and cytokines up-regulation

 2017 Dec 14;15:21. doi: 10.1186/s12948-017-0077-0. eCollection 2017.

Abstract

BACKGROUND:
The immunosenescence is a relatively recent chapter, correlated with the linear extension of the average life began in the nineteenth century and still in progress. The most important feature of immunosenescence is the accumulation in the "immunological space" of memory and effector cells as a result of the stimulation caused by repeated clinical and subclinical infections and by continuous exposure to antigens (inhalant allergens, food, etc.).

December 22, 2017

Feasibility of sustained response through long-term dosing in food allergy immunotherapy

  • Sandra Andorf,
  • Monali Manohar,
  • Tina Dominguez,
  • Whitney Block,
  • Dana Tupa,
  • Rohun A. Kshirsagar,
  • Vanitha Sampath,
  • R. Sharon Chinthrajah and
  • Kari C. NadeauEmail authorView ORCID ID profile
Contributed equally

Abstract
Background
Clinical trials using oral immunotherapy (OIT) for the treatment of food allergies have shown promising results. We previously demonstrated the feasibility of desensitization for up to 5 food allergens simultaneously through OIT. In this observational study, we report the findings of long-term follow-up (LTFU) of the participants treated through a single site OIT phase 1 trial.

December 20, 2017

Morphological characteristics and human papillomavirus genotype predict the treatment response in cutaneous warts

Early View
Browse  Early View Articles 
Online Version of Record published before inclusion in an issue 
Summary
Background
Cutaneous warts have a cure rate after therapy of no more than approximately 50%. Recently, we developed and validated a standard assessment tool for warts (Cutaneous WARTS diagnostic tool, CWARTS) based on phenotypical characteristics.

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