October 5, 2015

Health-related quality of life in patients with primary immunodeficiency disease


Open Access

Fonda Jiang13*Troy R. Torgerson12 and Andrew G. Ayars12

Primary immunodeficiency disease (PIDD) with hypogammaglobulinemia is characterized by recurrent and severe bacterial infections and IgG replacement is the standard of care in many of these patients. Health-related quality of life (HRQOL) is becoming increasingly recognized as a factor that affects patient well-being and treatment preferences. In an effort to better understand what factors affect HRQOL in patients with PIDD, we reviewed the published literature that used standardized instruments for the measurement of HRQOL.

Airway Smooth Muscle Phenotypes in Asthma - PartnersAsthmaCenter

Airway Smooth Muscle Phenotypes in Asthma

Xingbin Ai, Ph.D

October 4, 2015

Better management of cow's milk allergy using a very low dose food challenge test: A retrospective study

Allergology International
Vol. 64 (2015) No. 3 p. 272-276



Background: Low dose reactive cow's milk (CM) allergic children are at high risk of persistent CM allergy and a positive oral food challenge (OFC). The present study aimed to evaluate if the results of a very low dose (VL) OFC with these children contributes to better management of CM allergy.

Menopause as a predictor of new-onset asthma: A longitudinal Northern European population study


There is limited and conflicting evidence on the effect of menopause on asthma.


We sought to study whether the incidence of asthma and respiratory symptoms differ by menopausal status in a longitudinal population-based study with an average follow-up of 12 years.

October 3, 2015

Homo Nodus: Preparing For The Next Stage Of The Internet Of Things In Medical Education


Original Article
K Masters
The Internet of Things (IoT) is upon us.  The exact impact of the IoT on medical education is, as yet, unknown, but we do know that it promises great potential to be harnessed.

Dendritic cells revisited in human allergic rhinitis and asthma

  1. Antoine Froidure1,2,†
  2. Chong Shen1,†and
  3. Charles Pilette1,2,*
The role of dendritic cells (DCs) in airway allergy has been studied for 15 years, recent data has highlighted the cross-talk between with airway epithelial cells and environmental factors (allergens, virus) during the inception and exacerbation of allergic asthma.

October 2, 2015

The expanding role of immunopharmacology: IUPHAR Review 16

  1. Ekaterini Tiligada1,2,*
  2. Masaru Ishii3
  3. Carlo Riccardi4
  4. Michael Spedding5
  5. Hans-Uwe Simon6
  6. Mauro Martins Teixeira7
  7. Mario Landys Chovel Cuervo8
  8. Stephen T Holgate9 and
  9. Francesca Levi-Schaffer10

    1. Abstract: 
    2. Drugs targeting the immune system such as corticosteroids, antihistamines and immunosuppressants have been widely exploited in the treatment of inflammatory, allergic and autoimmune disorders during the second half of the 20th century. The recent advances in immunopharmacological research have made available new classes of clinically relevant drugs.

Drug Hypersensitivity in children: report from the pediatric task force of the EAACI Drug Allergy Interest Group

  1. Eva Gomes1,*
  2. Knut Brockow2
  3. Semanur Kuyucu3
  4. Francesca Saretta4
  5. Francesca Mori5
  6. Natalia Blanca-Lopez6
  7. Hagen Ott7,
  8. Marina Atanaskovic-Markovic8
  9. Mona Kidon9
  10. Jean-Christoph Caubet10
  11. Ingrid Terreehorst11 and
  12. The ENDA/EAACI Drug Allergy Interest Group

Abstract: When questioned, about 10% of the parents report suspected hypersensitivity to at least one drug in their children. However, only a few of these reactions can be confirmed as allergic after a diagnostic workup. There is still a lack of knowledge on drug hypersensitivity epidemiology, clinical spectrum and appropriate diagnostic methods particularly in children.

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