September 3, 2015

Effect of high-dose sublingual immunotherapy on respiratory infections in children allergic to house dust mite

Asia Pac Allergy. 2015 Jul;5(3):163-169. English.
http://dx.doi.org/10.5415/apallergy.2015.5.3.163 
Salvatore Barberi,1 Giorgio Ciprandi,2 Elvira Verduci,1 Enza D'Auria,1 Piercarlo Poli,1 Benedetta Pietra,1Cristoforo Incorvaia,3 Serena Buttafava,4 Franco Frati,4 and Enrica Riva1
1Department of Pediatrics, San Paolo Hospital, 20142 Milan, Italy.
2Department of Medicine, IRCCS-Azienda Ospedaliera Universitaria San Martino, 16132 Genoa, Italy.
3Allergy/Pulmonary Rehabilitation, ICP Hospital, 20100 Milan, Italy.
4Medical and Scientific Department, Stallergenes Italy, 20155 Milan, Italy.
Abstract
Background
Allergic rhinitis is characterized by eosinophil inflammation. Allergic inflammation may induce susceptibility to respiratory infections (RI). House dust mite (HDM) sensitization is very frequent in childhood. Allergen immunotherapy may cure allergy as it restores a physiologic immune and clinical tolerance to allergen and exerts anti-inflammatory activity.

September 2, 2015

Perinatal probiotic supplementation in the prevention of allergy related disease: 6 year follow up of a randomised controlled trial

Research article

Open Access

Melanie Rae Simpson1*Christian Kvikne Dotterud12Ola Storrø1Roar Johnsen1 and Torbjørn Øien1

Abstract
Background
Perinatal probiotics supplementation has been shown to be effective in the primary prevention of atopic dermatitis (AD) in early childhood, although the long term effects of probiotics on AD and other allergic diseases is less certain. We have previously reported a significant reduction in the cumulative incidence of AD at 2 years after maternal probiotic supplementation. In this study we present the effects of perinatal probiotics given to women from a general population on allergy related diseases in their offspring at 6 years.

Malaria eradication and elimination: views on how to translate a vision into reality

Highly AccessedForum

Open Access

Marcel Tanner12*Brian Greenwood3Christopher J M Whitty3Evelyn K Ansah4Ric N Price56Arjen M Dondorp67,Lorenz von Seidlein67J Kevin Baird68James G Beeson109Freya J I Fowkes1112139Janet Hemingway14Kevin Marsh15 and Faith Osier16
Abstract
Although global efforts in the past decade have halved the number of deaths due to malaria, there are still an estimated 219 million cases of malaria a year, causing more than half a million deaths. In this forum article, we asked experts working in malaria research and control to discuss the ways in which malaria might eventually be eradicated. Their collective views highlight the challenges and opportunities, and explain how multi-factorial and integrated processes could eventually make malaria eradication a reality.
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Characterization of Rhinitis According to the Asthma Status in Adults Using an Unsupervised Approach in the EGEA Study


Abstract
Background
The classification of rhinitis in adults is missing in epidemiological studies.
Objective
To identify phenotypes of adult rhinitis using an unsupervised approach (data-driven) compared with a classical hypothesis-driven approach.
Methods
983 adults of the French Epidemiological Study on the Genetics and Environment of Asthma (EGEA) were studied. Self-reported symptoms related to rhinitis such as nasal symptoms, hay fever, sinusitis, conjunctivitis, and sensitivities to different triggers (dust, animals, hay/flowers, cold air…) were used.

September 1, 2015

Immunological events in chronic spontaneous urticaria

Abstract

Chronic spontaneous urticaria (CSU) is a highly debilitating skin disease associated with systemic features. We have made significant progress in several aspects relating to this condition. However, the exact physiopathology remains unknown. There is mounting evidence for an autoimmune basis, demonstrated by the CSU serum ability to activate healthy donors skin mast cells and blood basophils. However, it is only seen among 35–40% of patients.

Does the Maternal Serum IgG Level during Pregnancy in Primary Antibody Deficiency Influence the IgG Level in the Newborn?

Case Reports in Immunology
Volume 2015 (2015), Article ID 286380, 4 pages
http://dx.doi.org/10.1155/2015/286380
Case Report

Vasantha Nagendran,1,2 Noel Emmanuel,3 and Amolak S. Bansal1

1Epsom and St Helier University Hospitals NHS Trust, Carshalton, Surrey SM5 1AA, UK
2St Georges University of London, London SW17 0RE, UK
3St George’s University Hospitals NHS Foundation Trust, Tooting, London SW17 0QT, UK
Received 18 June 2015; Revised 17 August 2015; Accepted 18 August 2015
Abstract
Purpose. To find out if the serum IgG level in the newborn baby was affected by low maternal serum IgG during pregnancy in two newly diagnosed primary antibody deficient patients. 

Effects of controlled diesel exhaust exposure on apoptosis and proliferation markers in bronchial epithelium – an in vivo bronchoscopy study on asthmatics, rhinitics and healthy subjects

Research article

Open Access

Annelie F Behndig1Karthika Shanmuganathan2Laura Whitmarsh2Nikolai Stenfors1Joanna L Brown2Anthony J Frew2Frank J Kelly3Ian S Mudway3Thomas Sandström1 and Susan J Wilson24*
Abstract
Background
Epidemiological evidence demonstrates that exposure to traffic-derived pollution worsens respiratory symptoms in asthmatics, but controlled human exposure studies have failed to provide a mechanism for this effect. Here we investigated whether diesel exhaust (DE) would induce apoptosis or proliferation in the bronchial epithelium in vivo and thus contribute to respiratory symptoms.

August 28, 2015

Personalized Immunomodulatory Therapy for Atopic Dermatitis: An Allergist’s View

Annals of Dermatology 2015 ; 27(4): 355~363 
Dong-Ho Nahm
Department of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, Korea
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
The current standard medical therapy for atopic dermatitis (AD) mainly focuses on symptomatic relief by controlling skin inflammation with topical corticosteroids and/or topical calcineurin inhibitors. However, the clinical efficacy of pharmacological therapy is often disappointing to both patients and physicians. The terminology of AD contains a historical meaning of eczematous dermatitis caused by hypersensitivity reaction to environmental inhalant or food allergen.

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