June 24, 2016

Markers of tolerance development to food allergens

  1. Marta Ponce1
  2. Susanne C. Diesner1
  3. Zsolt Szépfalusi1 and
  4. Thomas Eiwegger1,2,*
Abstract
IgE-mediated reactions to food allergens are the most common cause of anaphylaxis in childhood. Although allergies to cows milk, egg or soy proteins, in contrast to peanut and tree nut allergens, resolve within the first 6 years of life in up to 60% due to natural tolerance development, this process is not well understood.

June 23, 2016

How does the efficacy and safety of Oralair® compare to other products on the market?


Video abstract presented by Désirée Larenas-Linnemann. Abstract: Due to differences between allergen immunotherapy (AIT) trials in patient populations, trial design (including primary efficacy variables), the definition of a pollen season, data analysis
Désirée Larenas-Linnemann

Pediatric Allergy and Asthma Clinic, Department of Investigation, Hospital Médica Sur, México City, México

Abstract:
 Due to differences between allergen immunotherapy (AIT) trials in patient populations, trial design (including primary efficacy variables), the definition of a pollen season, data analysis, and comparisons between AIT products with existing data, is not possible nor valid. The efficacy of two grass pollen AIT tablets, Oralair® and Grazax®/Grastek®, should not be compared by looking at the percentage of score improvement in their respective trials.

June 22, 2016

Acoustic Rhinometry in Nasal Provocation Tests in Children and Adolescents

Wandalsen GF, Mendes AI, Matsumoto F, Solé D
Division of Allergy and Clinical Immunology, Department of Pediatrics, Federal University of São Paulo (UNIFESP), São Paulo, Brazil
Abstract
Objectives: To standardize acoustic rhinometry (AR) in nasal provocation tests (NPTs) with histamine in children and adolescents.

Patients and Methods: We performed a cross-sectional validation to compare AR with anterior active rhinomanometry (AAR) during histamine NPT in 20 children and adolescents with persistent allergic rhinitis and 20 controls. Changes in total nasal resistance (AAR) were compared with changes in nasal volume in the first 5 cm (V5). 

June 19, 2016

Effect of sodium hyluronate added to topical corticosteroids in chronic rhinosinusitis with nasal polyposis


Abstract:
Background: Available medical treatments for chronic rhinosinusitis (CRS) with nasal polyposis (CRSwNP) comprise systemic and topical therapies. Although topical corticosteroids are effective in the treatment of CRS, they are not completely devoid of adverse effects. Thus, care has to be taken when long-term treatments are prescribed. There is recent evidence that sodium hyaluronate (SH), the major component of many extracellular matrices, promotes tissue healing, including activation and moderation of the inflammatory responses, cell proliferation, migration, and angiogenesis.

Cross sectional questionnaire-based internet study: Self-perception and clinical course of drug allergy in Greece

Article in Press
Open Access
Abstract
Background
Data on self perception of drug allergy in the general population are lacking. Epidemiological studies focus either on specific populations or document adverse drug reactions in general. Our objective was to document self-reported drug allergy in Greece, through a simple, informative internet-based questionnaire.

June 18, 2016

IgE in the diagnosis and treatment of allergic disease

Weekly injection of histaglobulin produces long-term remission in chronic urticaria: A prospective clinical study

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Abstract
Objective:
Treatment of chronic urticaria (CU) can be difficult in many patients. Achieving long-term remission and reducing the requirement of antihistamines are vital in CU. The objective of this study was to assess the effectiveness of injection histaglobulin, a complex of histamine and human immunoglobulin, in producing relief in patients with CU.

June 17, 2016

Prediction of the Efficacy of Antihistamines in Chronic Spontaneous Urticaria Based on Initial Suppression of the Histamine- Induced Wheal

Sánchez J, Zakzuk J, Cardona R

Abstract

Background: Antihistamines are the first line of treatment for chronic spontaneous urticaria. However, there is no effective method to predict whether an antihistamine will have a beneficial clinical effect or not.

Objective: To assess whether the change in histamine-induced wheal and flare measurements 24 hours after administration of antihistamine can predict the efficacy of treatment.

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