June 28, 2015

Prolonged efficacy of the 300IR 5-grass pollen tablet up to 2 years after treatment cessation, as measured by a recommended daily combined score.

Open AccessResearch
Highly Accessed


Alain Didier1*Hans-Jørgen Malling2Margitta Worm3Friedrich Horak4 and Gordon L Sussman5

Abstract
Background
The 300IR (index of reactivity) 5-grass pollen tablet has favorable short-term and sustained clinical efficacy in patients with grass pollen-induced allergic rhinoconjunctivitis (ARC). Here, we report maintenance of efficacy and safety over 2 years following treatment discontinuation.

Use of a basophil activation test as a complementary diagnostic tool in the diagnosis of severe peanut allergy in adults

Highly AccessedOpen Access
Research


Georgios Rentzos14*Vanja Lundberg2Christina Lundqvist2Rui Rodrigues3Jenny van Odijk1Anna-Carin Lundell2,Teet Pullerits1 and Esbjörn Telemo2

Abstract
Background
Diagnosis of severe peanut allergy is difficult and delays in making an accurate diagnosis may place the patient at risk. Adults with a history of anaphylaxis must strictly avoid any contact with peanuts or products that may contain traces of peanuts.

Identification of risk factors of severe hypersensitivity reactions in general anaesthesia

Open Access
Research


Corrado Mirone1Donatella Preziosi1Ambra Mascheri1Gianluigi Micarelli1Laura Farioli2Luca G Balossi1Joseph Scibilia1Jan Schroeder1Laura M Losappio1Maria G Aversano1Chrysi Stafylaraki1Michele Nichelatti3 and Elide A Pastorello4*

Abstract
Background
Hypersensitivity reactions to anaesthetic agents are rare but often severe, with a mortality ranging from 4 to 9% in IgE-mediated events. Identification of the risk factors may contribute to limit the incidence of these reactions. The aim of our study was to search for possible risk factors of severe perioperative hypersensitivity reactions in our study population.

Choosing wisely: practical considerations on treatment efficacy and safety of asthma in the elderly

Open Access
Review


Nicola Scichilone1*Maria T Ventura2Matteo Bonini3Fulvio Braido4Caterina Bucca5Marco Caminati6Stefano Del Giacco7Enrico Heffler8Carlo Lombardi9Andrea Matucci10Manlio Milanese11Roberto Paganelli12Giovanni Passalacqua4Vincenzo Patella13Erminia Ridolo14Giovanni Rolla15Oliviero Rossi16Domenico Schiavino17,Gianenrico Senna6Gundi Steinhilber18Alessandra Vultaggio10 and Giorgio Canonica4

Clinical and Molecular Allergy 2015, 13:7  doi:10.1186/s12948-015-0016-x
Nicola Scichilone and Maria T Ventura contributed equally to this work.
Published: 22 June 2015
Abstract
The prevalence of asthma in the most advanced ages is similar to that of younger ages. However, the concept that older individuals may suffer from allergic asthma has been largely denied in the past, and a common belief attributes to asthma the definition of “rare” disease. Indeed, asthma in the elderly is often underdiagnosed or diagnosed as COPD, thus leading to undertreatment of improper treatment.

June 25, 2015

Control of asthma in real life: still a valuable goal?

  1. Mina Gaga2
+Author Affiliations
  1. 12nd Respiratory Medicine Dept, University of Athens Medical School, Attikon Hospital, Athens, Greece
  2. 27th Respiratory Medicine Dept and Asthma Center, Athens Chest Hospital “Sotiria”, Athens, Greece
  1. Mina Gaga, 7th Respiratory Dept and Asthma Center, Athens Chest Hospital “Sotiria”, Athens 11527, Greece. E-mail: minagaga@yahoo.com

Abstract
Although studies show that control of asthma can be achieved in the majority of patients, surveys repeatedly show that this is not the case in real life. Important measures to implement in order to achieve asthma control are trained healthcare professionals, a good patient–doctor relationship, patient education, avoidance of exposure to triggers, personalised management and adherence to treatment.

Genome-Wide Association Study Identifies Novel Pharmacogenomic Loci For Therapeutic Response to Montelukast in Asthma



Abstract

BACKGROUND:

Genome-wide association study (GWAS) is a powerful tool to identify novel pharmacogenetic single nucleotide polymorphisms (SNPs). Leukotriene receptor antagonists (LTRAs) are a major class of asthma medications, and genetic factors contribute to variable responses to these drugs. We used GWAS to identify novel SNPs associated with the response to the LTRA, montelukast, in asthmatics.

June 24, 2015

Matching science and practice in the management of allergic disorders



EAACI Congress 2015
6 - 10 June 2015, Barcelona

Industry Sponsored Sessions
Webcasts


Grupo UriachMONDAY, 8 JUNE 2015

Matching science and practice in the management of allergic disorders

Chairs: Victoria Cardona, Spain and Jean Bousquet, France

Back to the future: the IgE journey in asthma, chronic spontaneous urticaria and beyond


EAACI Congress 2015
6 - 10 June 2015, Barcelona

Industry Sponsored Sessions
Webcasts

NOVARTIS PHARMACEUTICALS

Novartis PharmaceuticalsSUNDAY, 7 JUNE 2015

Back to the future: the IgE journey in asthma, chronic spontaneous urticaria and beyond

Chairs: Stephen Holgate, UK and Ana Giménez-Arnau, Spain

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