December 18, 2014

In silico analysis of autoimmune diseases and genetic relationships to vaccination against infectious diseases

Research articleOpen Access
Peter B McGarvey12*Baris E Suzek126James N Baraniuk3Shruti Rao1Brian Conkright1Samir Lababidi4Andrea Sutherland45Richard Forshee4 and Subha Madhavan1
Near universal administration of vaccines mandates intense pharmacovigilance for vaccine safety and a stringently low tolerance for adverse events. Reports of autoimmune diseases (AID) following vaccination have been challenging to evaluate given the high rates of vaccination, background incidence of autoimmunity, and low incidence and variable times for onset of AID after vaccinations.

High-dose intravenous immunoglobulin therapy for eosinophilic granulomatosis with polyangiitis

ResearchOpen Access

Naomi TsurikisawaHiroshi SaitoChiyako OshikataTakahiro Tsuburai and Kazuo Akiyama
Regulatory T (Treg) cells are implicated in the development and progression of eosinophilic granulomatosis with polyangiitis (EGPA). We previously showed beneficial effects of intravenous immunoglobulin (IVIG) therapy combined with corticosteroid and immunosuppressant treatment on clinical symptoms, including mononeuritis multiplex and cardiac dysfunction, and Treg cell frequency, during EGPA.

December 17, 2014

Effects of Bifidobacterial Supplementation to Pregnant Women and Infants in the Prevention of Allergy Development in Infants and on Fecal Microbiota

Tadao Enomoto, Masanori Sowa, Keiji Nishimori, Shinichiro Shimazu, Akira Yoshida, Kazuko Yamada, Fukumi Furukawa,Takemasa Nakagawa, Naotake Yanagisawa, Noriyuki Iwabuchi, Toshitaka Odamaki, Fumiaki Abe, Jiro Nakayama, Jin-zhong Xiao

Background: Probiotic administration may be a useful method for preventing allergies in infants; however, there have been controversial results about the efficacy. We investigated the effects of bifidobacterial supplementation on the risk of developing allergic diseases in the Japanese population.

Novel in silico technology in combination with microarrays: a state-of-the-art technology for allergy diagnosis and management?

, and 
Allergy and Respiratory Diseases, Department of Internal Medicine, IRCCS S.Martino-IST-University of Genoa, 
Largo Rosanna Benzi 10,16132, Genova,

Japanese Guideline for Food Allergy 2014

Atsuo Urisu, Motohiro Ebisawa, Komei Ito, Yukoh Aihara, Setsuko Ito, Mitsufumi Mayumi, Yoichi Kohno, Naomi Kondo, on behalf of Committee for Japanese Pediatric Guideline for Food Allergy, Japanese Society of Pediatric Allergy and Clinical Immunology and Japanese Society of Allergology 

A food allergy is defined as "a phenomenon in which adverse reactions are caused through antigen-specific immunological mechanisms after exposure to given food."

Effects of TNF-α Polymorphisms on Asthma Risk: A Systematic Review and Meta-Analysis

H Huang,*1 W Nie,*1 J Qian,*2 Y Zang,*1 J Chen,*1 G Lai,*3 T Ye,*1 Q Xiu1
1Department of Respiratory Disease, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
2Department of Neurosurgery, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, China
3Department of Respiratory Medicine, Fuzhou Military General Hospital, Fuzhou, Fujian, China
*These authors contributed equally to this work..

December 15, 2014

Examination of genetic variants involved in generation and biodisposition of kinins in patients with angioedema

ResearchOpen Access
Published: 12 December 2014
Abstract (provisional)

Jonathan Levy1*Georges-Etienne Rivard2Eric Wagner3Don Beezhold4Noam Berlin5Li Fan2Zhao Zhang2 and Gordon L Sussman5
Angioedema (AE) is idiopathic in the majority of cases. We studied patients with AE for genetic variants of proteins involved with bradykinin generation and biodisposition.

Anaphylaxis caused by tipepidine hibenzate, a central antitussive drug

Cover image for Vol. 2 Issue 4


Tipepidine hibenzate, a central antitussive drug, is widely used in the management of cough and is generally safe and well tolerated. We present here a case of anaphylaxis caused by this drug.

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