September 19, 2014

IgG4-related disease and its pathogenesis— cross-talk between innate and acquired immunity

      Hisanori Umehara1,2,5, Akio Nakajima1, Takuji Nakamura1, Takafumi Kawanami1, Masao Tanaka1, Lingli Dong3 and Mitsuhiro Kawano4

+Author Affiliations
  1. 1 Department of Internal Medicine, Division of Hematology and Immunology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa 920-0293, Japan
  2. 2 Department of Clinical Immunology, Graduate School of Medicine and Faculty of Medicine, Kyoto UniversityKyoto 606-8501, Japan
  3. 3 Department of Hematology and Immunology, Tongji Hospital, Huazhong University of Science and TechnologyWuhan, Hubei 430030, China
  4. 4 Department of Internal Medicine, Division of Rheumatology, Graduate School of Medical Science, Kanazawa UniversityKanazawa, Ishikawa 920-8641, Japan
  5. 5Present address: Department of Clinical Immunology, Graduate School of Medicine and Faculty of Medicine, Kyoto University, Kyoto 606-8501, Japan
  1. Correspondence to: H. Umehara; E-mail: umehara606@gmail.com
  • Received October 26, 2013.
  • Revision received July 2, 2014.
  • Accepted July 3, 2014.

Abstract

IgG4-related disease (IgG4-RD) is a novel clinical entity proposed in Japan in the 21th century and is attracting strong attention over the world. The characteristic manifestations of IgG4-RD are increased serum IgG4 concentration and tumefaction by IgG4+ plasma cells. Although the clinical manifestations in various organs have been established, the pathogenesis of IgG4-RD is still unknown. Recently, many reports of aberrant acquired immunity such as Th2-diminated immune responses have been published. However, many questions still remain, including questions about the pathogenesis of IgG4-RD and the roles of IgG4. In this review, we discuss the pathogenesis of IgG4-RD by focusing on the cross-talk between innate and acquired immunity.
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  1. Int. Immunol.doi10.1093/intimm/dxu074
  1. This article is Open Access
  2. All Versions of this Article:
    1. dxu074v1
    2. dxu074v2 most recent
© The Author 2014. Published by Oxford University Press on behalf of The Japanese Society for Immunology.
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