- Springer Open Choice
- PMC4243008
Drug Safety
Drug Saf. 2014; 37(12): 1037–1045.Hisham M. R. B. Omer, James Hodson, Sarah K. Thomas,
and Jamie J. ColemanAuthor information ► Copyright and License information ►Abstract
Background
The term multiple drug intolerance syndrome (MDIS) has been used to describe patients who express adverse drug reactions to three or more drugs without a known immunological mechanism.
Objective
To identify patient factors that could increase the risk of MDIS.
Method
Inpatient records over a 5-year period were captured from an electronic prescribing system to identify patients with at least one documented drug allergy. Univariable and multivariable analyses were used to compare the rates of MDIS across age, sex, weight, ethnicity, history of atopy or psychological disorders, and previous admissions.
Results
A total of 25,695 patients had a documented drug intolerance, 4.9 % of whom had MDIS. MDIS was significantly more likely in women (p < 0.001), patients with multiple comorbidities (p < 0.001), and patients with previous hospital admissions (p < 0.001). With the exception of penicillin (p = 0.749), MDIS was more frequent in those with allergies to other drugs (p < 0.001).
Conclusion
MDIS was associated with female gender, multiple comorbidities, and previous hospital admissions. A documented allergy to penicillin did not increase the likelihood of MDIS.
The term multiple drug intolerance syndrome (MDIS) has been used to describe patients who express adverse drug reactions to three or more drugs without a known immunological mechanism.
To identify patient factors that could increase the risk of MDIS.
Inpatient records over a 5-year period were captured from an electronic prescribing system to identify patients with at least one documented drug allergy. Univariable and multivariable analyses were used to compare the rates of MDIS across age, sex, weight, ethnicity, history of atopy or psychological disorders, and previous admissions.
A total of 25,695 patients had a documented drug intolerance, 4.9 % of whom had MDIS. MDIS was significantly more likely in women (p < 0.001), patients with multiple comorbidities (p < 0.001), and patients with previous hospital admissions (p < 0.001). With the exception of penicillin (p = 0.749), MDIS was more frequent in those with allergies to other drugs (p < 0.001).
MDIS was associated with female gender, multiple comorbidities, and previous hospital admissions. A documented allergy to penicillin did not increase the likelihood of MDIS.
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Abstract
Background
The term multiple drug intolerance syndrome (MDIS) has been used to describe patients who express adverse drug reactions to three or more drugs without a known immunological mechanism.
Objective
To identify patient factors that could increase the risk of MDIS.
Method
Inpatient records over a 5-year period were captured from an electronic prescribing system to identify patients with at least one documented drug allergy. Univariable and multivariable analyses were used to compare the rates of MDIS across age, sex, weight, ethnicity, history of atopy or psychological disorders, and previous admissions.
Results
A total of 25,695 patients had a documented drug intolerance, 4.9 % of whom had MDIS. MDIS was significantly more likely in women (p < 0.001), patients with multiple comorbidities (p < 0.001), and patients with previous hospital admissions (p < 0.001). With the exception of penicillin (p = 0.749), MDIS was more frequent in those with allergies to other drugs (p < 0.001).
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