Choosing wisely: practical considerations on treatment efficacy and safety of asthma in the elderly

Review

Nicola Scichilone^1*†, Maria T Ventura^2†, Matteo Bonini³, Fulvio Braido⁴, Caterina Bucca⁵, Marco Caminati⁶, Stefano Del Giacco⁷, Enrico Heffler⁸, Carlo Lombardi⁹, Andrea Matucci¹⁰, Manlio Milanese¹¹, Roberto Paganelli¹², Giovanni Passalacqua⁴, Vincenzo Patella¹³, Erminia Ridolo¹⁴, Giovanni Rolla¹⁵, Oliviero Rossi¹⁶, Domenico Schiavino¹⁷,Gianenrico Senna⁶, Gundi Steinhilber¹⁸, Alessandra Vultaggio¹⁰ and Giorgio Canonica⁴

Clinical and Molecular Allergy 2015, 13:7  doi:10.1186/s12948-015-0016-x

Nicola Scichilone and Maria T Ventura contributed equally to this work.

Published: 22 June 2015

Abstract

The prevalence of asthma in the most advanced ages is similar to that of younger ages. However, the concept that older individuals may suffer from allergic asthma has been largely denied in the past, and a common belief attributes to asthma the definition of “rare” disease. Indeed, asthma in the elderly is often underdiagnosed or diagnosed as COPD, thus leading to undertreatment of improper treatment.

This is also due to the heterogeneity of clinical and functional presentations of geriatric asthma, including the partial loss of reversibility and the lower occurrence of the allergic component in this age range. The older asthmatic patients are also characterized the coexistence of comorbid conditions that, in conjunction with age-associated structural and functional changes of the lung, may contribute to complicate the management of asthma. The current review addresses the main issues related to the management of allergic asthma in the geriatric age. In particular, the paper aims at revising current pharmacological and non pharmacological treatments for allergic asthmatics of advanced ages, primarily focusing on their safety and efficacy, although most behaviors are an arbitrary extrapolation of what has been tested in young ages. In fact, age has always represented an exclusion criterion for eligibility to clinical trials. Experimental studies and real life observations specifically testing the efficacy and safety of therapeutic approaches in allergic asthma in the elderly are urgently needed.

Keywords: 

Aging; Asthma; Allergy; Therapy 

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