August 21, 2016

Specific immunotherapy ameliorates ulcerative colitis


  • Min Cai,
  • Lu Zeng,
  • Lin-Jing Li,
  • Li-Hua Mo,
  • Rui-Di Xie,
  • Bai-Sui Feng,
  • Peng-Yuan Zheng,
  • Zhi-Gang Liu,
  • Zhan-Ju Liu
  • and
  • Ping-Chang Yang
  • Background
    Hypersensitivity reaction to certain allergens plays a role in the pathogenesis of inflammatory bowel disease (IBD). This study aims to observe the effect of specific immunotherapy in a group of IBD patients.
    Methods
    Patients with both ulcerative colitis (UC) and food allergy were recruited into this study. Food allergy was diagnosed by skin prick test and serum specific IgE. The patients were treated with specific immunotherapy (SIT) and Clostridium butyricum (CB) capsules.
    Results
    After treating with SIT and CB, the clinical symptoms of UC were markedly suppressed as shown by reduced truncated Mayo scores and medication scores. The serum levels of specific IgE, interleukin (IL)-4 and tumor necrosis factor (TNF)-α were also suppressed. Treating with SIT alone or CB alone did not show appreciable improvement of the clinical symptoms of UC.
    Conclusions
    UC with food allergy can be ameliorated by administration with SIT and butyrate-production probiotics.

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