December 22, 2017

Feasibility of sustained response through long-term dosing in food allergy immunotherapy

  • Sandra Andorf,
  • Monali Manohar,
  • Tina Dominguez,
  • Whitney Block,
  • Dana Tupa,
  • Rohun A. Kshirsagar,
  • Vanitha Sampath,
  • R. Sharon Chinthrajah and
  • Kari C. NadeauEmail authorView ORCID ID profile
Contributed equally

Abstract
Background
Clinical trials using oral immunotherapy (OIT) for the treatment of food allergies have shown promising results. We previously demonstrated the feasibility of desensitization for up to 5 food allergens simultaneously through OIT. In this observational study, we report the findings of long-term follow-up (LTFU) of the participants treated through a single site OIT phase 1 trial.
Methods
The participants (n = 46) were followed up to 72 months since the time they reached 2 g maintenance dose per food in the initial phase 1 trial. During the long-term maintenance dosing, participants continued or reduced the initial maintenance dose of food allergen protein to high (median 2 g protein) vs. low (median 300 mg protein). Participant follow-up included clinical monitoring, standardized OFCs, and in some cases, skin prick tests and measurement of allergen-specific IgE and IgG4.
Results
Irrespective of the high vs. low long-term maintenance dose during LTFU, all participants were able to ingest 2 g protein of each food allergen protein during OFCs performed at the end of our LTFU.
Conclusion
Our LTFU cohort of food OIT participants from a single site, phase 1 OIT study, supports the feasibility of sustained desensitization through long-term maintenance dosing.

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