September 15, 2014

Lactobacilli regulate Staphylococcus aureus 161:2-induced pro-inflammatory T-cell responses in vitro


Department of Molecular Biosciences, the Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.

Exogenous interleukin-10 alleviates allergic inflammation but inhibits local interleukin-10 expression in a mouse allergic rhinitis model.

Research article

Open Access

Shui-Bin Wang13Yu-Qin Deng1Jie Ren1Bo-Kui Xiao1Zheng Liu2* and Ze-Zhang Tao1*
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Twenty-first century mast cell stabilizers

Impact of endobronchial allergen provocation on macrophage phenotype in asthmatics

Research article

Open Access

Carla Winkler12Lena Witte12Natali Moraw2Conny Faulenbach2Meike Müller2Olaf Holz23Frank Schaumann2 and Jens M Hohlfeld123*

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Depigmented-polymerised allergoids favour regulatory over effector T cells: enhancement by 1α, 25-dihydroxyvitamin D3

Research article

Zoe L Urry1David F Richards1Cheryl Black1Maria Morales2Jerónimo Carnés2,Catherine M Hawrylowicz1* and Douglas S Robinson3*

1Department of Allergy and Asthma, MRC and Asthma UK Centre for Mechanisms of Allergic Asthma, Guy’s Campus, King’s College London, London, UK
2Department of Research and Development, Laboratorios Leti, Tres Cantos, Madrid, Spain
3Leukocyte Biology Section, MRC and Asthma UK Centre for Mechanisms of Allergic Asthma, NHLI, Imperial College London, London, UK
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The electronic version of this article is the complete one and can be found online at:http://www.biomedcentral.com/1471-2172/15/21

Received:30 October 2013
Accepted:16 May 2014
Published:29 May 2014
© 2014 Urry et al.; licensee BioMed Central Ltd. 
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

September 14, 2014

A Long-Term Risk? Prenatal POPs Exposure and Asthma in Young Adults


Lindsey Konkel is a Worcester, MA–based journalist who reports on science, health, and the environment. She is an editor for Environmental Health News and The Daily Climate.
About This Article open

“The focus in immunotoxicity studies has often been on immunologic intermediates, such as immune cell counts. This study is unique in that it looks at a long-term clinically relevant outcome,” says Todd Jusko, an environmental epidemiologist at the University of Rochester, who was not involved in the study.
lthough previous research has suggested that prenatal exposures to persistent organic pollutants (POPs) may be harmful to a child’s developing immune system,1 few studies have investigated long-term outcomes in this regard. Findings reported in this issue of EHP provide evidence that exposure to certain POPs in the womb may be associated with an increased risk of developing asthma that persists into young adulthood.2

Asthma and respiratory physiology: Putting lung function into perspective

September 13, 2014

A genome-wide association study of bronchodilator response in asthmatics


Pharmacogenomics J. Author manuscript; available in PMC Aug 1, 2014.
Published in final edited form as:
Published online Mar 19, 2013. doi:  10.1038/tpj.2013.5
PMCID: PMC3706515
NIHMSID: NIHMS442409

A genome-wide association study of bronchodilator response in asthmatics

Qing Ling Duan, PhD,1,* Jessica Lasky-Su, ScD,1,* Blanca E. Himes, PhD,1,2 Weiliang Qiu, PhD,1 Augusto A. Litonjua, MD, MPH,1,3 Amy Damask, PhD,5 Ross Lazarus, MB, BS,1 Barbara Klanderman, PhD,1 Charles G. Irvin, PhD,6Stephen P. Peters, MD, PhD,7 John P. Hanrahan, MD, MPH,8 John J. Lima, PharmD,9 Fernando D. Martinez, MD,10David Mauger, PhD,11 Vernon M. Chinchilli, PhD,11 Manuel Soto-Quiros, PhD,12 Lydiana Avila, MD,12 Juan C. Celedón, MD, DrPH,13 Christoph Lange, PhD,4 Scott T. Weiss, MD, MS,1,2,3,4 and Kelan G. Tantisira, MD, MPH1,3