Japanese guideline for adult asthma 2014

doi:10.2332/allergolint. 14-RAI-0766

Ken Ohta, Masakazu Ichinose, Hiroyuki Nagase, Masao Yamaguchi, Hisatoshi Sugiura, Yuji Tohda, Kohei Yamauchi, Mitsuru Adachi, Kazuo Akiyama and Japanese Society of Allergology

ABSTRACT

Adult bronchial asthma (hereinafter, asthma) is characterized by chronic airway inflammation, reversible airway narrowing, and airway hyperresponsiveness. Long-standing asthma induces airway remodeling to cause intractable asthma.

Peanut immunotherapy

Review

Katherine Anagnostou and Andrew Clark

Author Affiliations

For all author emails, please log on.

Clinical and Translational Allergy 2014, 4:30  doi:10.1186/2045-7022-4-30

Published: 25 September 2014

Abstract (provisional)

Peanut allergy is common and can be a cause of severe, life-threatening reactions. It is rarely outgrown like other food allergies, such as egg and milk.

New product development with the innovative biomolecular sublingual immunotherapy formulations for the management of allergic rhinitis

Authors Frati F, Cecchi L, Scala E, Ridolo E, Dell'Albani I, Makrì E, Pajno G, Incorvaia C

Published Date September 2014 Volume 2014:8 Pages 221—226

DOI http://dx.doi.org/10.2147/BTT.S50951

Received 21 May 2014, Accepted 24 July 2014, Published 12 September 2014

Approved for publication by Dr Doris Mangiaracina Benbrook

Abstract: The molecular allergy technique, currently defined as component-resolved diagnosis, significantly improved the diagnosis of allergy, allowing for differentiation between molecules actually responsible for clinical symptoms (genuine sensitizers) and those simply cross-reacting or shared by several sources (panallergens), thus influencing the appropriate management of a patient's allergy.

Efficacy and Safety of Inhaled and Intranasal Corticosteroids

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents)

DOI: 10.2174/1871523013666140826115204

Author(s): Akefeh Ahmadiafshar and Sahar Ahmadiafshar

Abstract:

Inflammation is an important phenomenon in allergic disorders and corticosteroid drugs since their anti inflammatory properties have a pivotal role in improvement, control and relieving the symptoms and signs of asthma, allergic rhinitis, atopic dermatitis and many other inflammatory disorders.

Mast cells and basophils in cutaneous immune responses

Atsushi Otsuka and Kenji Kabashima

Allergy (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)

Abstract

Mast cells and basophils share some functions in common and are generally associated with T helper 2 (Th2) immune responses, but taking basophils as surrogate cells for mast cell research or vice versa for several decades is problematic. Thus far, their in vitro functions have been well studied, but their in vivo functions remained poorly understood.

Elucidation of pathways driving asthma pathogenesis: development of a systems-level analytic strategy

Front. Immunol., 23 September 2014 | doi: 10.3389/fimmu.2014.00447

Michael L. Walker¹, Kathryn E. Holt^2,3, Gary P. Anderson⁴, Shu Mei Teo^1,2, Peter D. Sly⁵, Patrick G. Holt^3,5* and Michael Inouye^1,3,6

• 1Medical Systems Biology, Department of Pathology, The University of Melbourne, Parkville, VIC, Australia
• 2Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, Australia
• 3Telethon Kids Institute, The University of Western Australia, West Perth, WA, Australia
• 4Department of Pharmacology and Therapeutics, Lung Health Research Centre, The University of Melbourne, Melbourne, VIC, Australia
• 5Queensland Children’s Medical Research Institute, The University of Queensland, Brisbane, QLD, Australia
• 6Medical Systems Biology, Department of Microbiology and Immunology, The University of Melbourne, Parkville, VIC, Australia

Asthma is a genetically complex, chronic lung disease defined clinically as episodic airflow limitation and breathlessness that is at least partially reversible, either spontaneously or in response to therapy.

Changes in Allergen Sensitization Over The Last 30 Years in Korea Respiratory Allergic Patients: A Single-Center

Allergy Asthma Immunol Res. 2014 Sep;6(5):434-443. English. Published online Jul 09, 2014.  http://dx.doi.org/10.4168/aair.2014.6.5.434

Copyright © 2014 The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease

Hye Jung Park,1,2 Hyun Sun Lim,3 Kyung Hee Park,1,2 Jae-Hyun Lee,1,2 Jung-Won Park,1,2 and Chein-Soo Hong1,2

1Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

2Institute of Allergy, Yonsei University College of Medicine, Seoul, Korea.

3Biomedical Research Center, Yonsei University College of Medicine, Seoul, Korea.

Work-related airway symptoms, nasal reactivity and health-related quality of life in female hairdressers: a follow-up study during exposure

Go to:

Abstract

Objectives

Hairdressers often complain of work-related rhinitis (WR). They are infrequently sensitized to persulphates. The cause and mechanism of the symptoms and the effects on their health-related quality of life (HRQoL) remains unclear. The objectives were to follow female hairdressers with WR mainly from bleaching powder regarding nasal reactivity to persulphate and to evaluate symptoms, HRQoL and inflammatory markers in nasal lavage during a working period after vacation and compared with hairdressers without symptoms and pollen allergic women.

Methods

Skin prick tests to persulphate were performed in the hairdressers. Participants kept a diary of symptoms and of work tasks (hairdressers only). They completed HRQoL questionnaires. Eosinophil cationic protein (ECP) in nasal lavage fluid was examined. The symptomatic hairdressers performed nasal challenges with persulphate before and after the exposure.

Results

Skin prick tests were negative. Although the nasal reactivity to persulphate did not change a steady increase in nasal symptoms, especially blockage, and in ECP was noticed in the symptomatic hairdressers. The HRQoL deteriorated in the symptomatic hairdressers indicating an effect on their working situation and daily life. The atopics had more, but varying symptoms (itching, sneezing and secretion).

Conclusions

The difference in the clinical picture between the symptomatic hairdressers and the pollen allergic women, the increase in symptoms and ECP in the nasal lavage support the view that a sensitization to hairdresser chemicals by a mechanism not yet understood is operating. The deterioration of the HRQoL in the symptomatic hairdressers indicates a considerable effect on their life.

Keywords: 

Int Arch Occup Environ Health. 2014; 87(1): 61–71.

Published online Dec 23, 2012. doi:  10.1007/s00420-012-0835-8

PMCID: PMC3880473

K. Kronholm Diab, B. A. G. Jönsson, A. Axmon, and J. Nielsen

Author information ► Article notes ► Copyright and License information ►