Executive summary
The 2015 Lancet Commission on Health and Climate
Change has been formed to map out the impacts of
climate change, and the necessary policy responses, in
order to ensure the highest attainable standards of health
for populations worldwide. This Commission is multidisciplinary
and international in nature, with strong
collaboration between academic centres in Europe and
China.
The central finding from the Commission’s work is
that tackling climate change could be the greatest global
health opportunity of the 21st century. The key messages
from the Commission are summarised below,
accompanied by ten underlying recommendations to
accelerate action in the next 5 years.
Published online June 23, 2015 http://dx.doi.org/10.1016/S0140-6736(15)60854-63 Full text pdf
A blog that publishes updates and open access scientific papers about allergy, asthma and immunology. Editor: Juan Carlos Ivancevich, MD. Specialist in Allergy & Immunology
June 24, 2015
June 23, 2015
H1-antihistamines for primary mast cell activation syndromes (MCAS): a systematic review
- Ulugbek B. Nurmatov1,*,
- Edmund Rhatigan2,
- F. Estelle R. Simons3 and
- Aziz Sheikh1,4
Allergy
Abstract
Background
Primary mast cell activation syndromes (MCAS) are a group of disorders presenting with symptoms of mast cell mediator release.
Objectives
To assess the effectiveness and safety of orally-administered H1-antihistamines in the treatment of primary MCAS compared with placebo and other pharmacologic treatments.
Risk of Obstructive Sleep Apnea in Adult Patients with Asthma: A Population-Based Cohort Study in Taiwan
OPEN ACCESS
PEER-REVIEWED
RESEARCH ARTICLE
June 22, 2015
EAACI IG Biologicals task force paper on the use of biologic agents in allergic disorders
- O. Boyman1,*,
- C. Kaegi1,
- M. Akdis2,3,
- S. Bavbek4,
- A. Bossios5,
- A. Chatzipetrou6,
- T. Eiwegger7,
- D. Firinu8,
- T. Harr9,
- E. Knol10,
- A. Matucci11,
- O. Palomares12,
- C. Schmidt-Weber13,
- H.-U. Simon14,
- U. C. Steiner15,
- A. Vultaggio11,
- C. A. Akdis2,3and
- F. Spertini12
Allergy Volume 70, Issue 7, pages 727–754, July 2015
Keywords:
- allergic rhinitis;
- asthma;
- atopic dermatitis;
- eosinophilic disorders;
- food allergy;
- hymenoptera allergy;
- urticaria
- allergic rhinitis;
- asthma;
- atopic dermatitis;
- eosinophilic disorders;
- food allergy;
- hymenoptera allergy;
- urticaria
Abstract
Biologic agents (also termed biologicals or biologics) are therapeutics that are synthesized by living organisms and directed against a specific determinant, for example, a cytokine or receptor. In inflammatory and autoimmune diseases, biologicals have revolutionized the treatment of several immune-mediated disorders.
Biologic agents (also termed biologicals or biologics) are therapeutics that are synthesized by living organisms and directed against a specific determinant, for example, a cytokine or receptor. In inflammatory and autoimmune diseases, biologicals have revolutionized the treatment of several immune-mediated disorders.
Asthma phenotyping: a necessity for improved therapeutic precision and new targeted therapies
Journal of Internal Medicine
- Kian Fan Chung
Article first published online: 15 JUN 2015 DOI: 10.1111/joim.12382
Keywords:
- asthma clusters;
- asthma phenotyping;
- asthma treatments;
- eosinophils;
- neutrophils;
- T helper type 2 (Th2)
Abstract
Asthma is a common heterogeneous disease with a complex pathophysiology that carries a significant mortality rate and high morbidity. Current therapies based on inhaled corticosteroids and long-acting ÎČ-agonists remain effective in a large proportion of patients with asthma, but ~10% (considered to have ‘severe asthma’) do not respond to these treatments even at high doses or with the use of oral corticosteroids. Analytical clustering methods have revealed phenotypes that include dependence on high-dose corticosteroid treatment, severe airflow obstruction and recurrent exacerbations associated with an allergic background and late onset of disease.
June 19, 2015
The Allergies, Immunotherapy, and RhinoconjunctivitiS (AIRS) survey: provider practices and beliefs about allergen immunotherapy
- Bryan Leatherman MD1,*,
- David P. Skoner MD2,3,
- James A. Hadley MD, FACS4,
- Nicole Walstein PA-C5,
- Michael S. Blaiss MD6,
- Mark S. Dykewicz MD7,
- Timothy Craig DO8,
- Nancy Smith MS9 and
- Felicia Allen-Ramey PhD10
International Forum of Allergy & Rhinology
Keywords:
- physician's practice patterns;
- allergens;
- subcutaneous immunotherapy;
- sublingual immunotherapy;
- administration and dosage;
- immunology
Background
The practices and beliefs of the provider specialties that treat allergic rhinoconjunctivitis (ARC) with allergen immunotherapy (AIT) may vary.
Methods
A telephone survey of 500 randomly selected health care practitioners in 7 specialties, conducted in 2012.
June 18, 2015
Maculopapular eruption and fever due to lamotrigine followed by subsiding flare-ups
This article is part of the supplement: Abstracts from the EAACI Skin Allergy Meeting 2014
Introduction
Lamotrigine (LTG), an aromatic antiepileptic drug, is mainly used to manage epilepsy and bipolar / mood disorders. Skin rashes are the most common adverse reaction to this drug that typically develop in the first 8 weeks of treatment.
Case presentation
A 27-year-old Caucasian woman treated with LTG 25 mg PO for a depressive episode was hospitalized in our allergy clinic with highly pruritic maculopapular eruption (MPE), affecting her abdomen, chest, back and forearms, which had started 2 days earlier along with fever of 37.5ÂșC. A well-defined red dermographism and tenderness of the skin was observed.
Hypersensitivity to Tomato (Lycopersicon esculentum) in Peach-Allergic Patients: rPru p 3 and rPru p 1 Are Predictive of Symptom Severity
Mascheri A1, Farioli L2, Pravettoni V3, Piantanida M3, Stafylaraki C1, Scibilia J1, Mirone C1, Preziosi D1, Nichelatti M4, Pastorello EA5
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1Allergology and Immunology Unit, Niguarda Ca’ Granda Hospital, Milan, Italy
2Department of Laboratory Medicine, Niguarda Ca’ Granda Hospital, Milan, Italy 3Clinical Allergy and Immunology Unit, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy 4Service of Biostatistics, Niguarda Ca’ Granda Hospital, Milan, Italy 5Allergology and Immunology Unit, Niguarda Ca’ Granda Hospital and Department of Clinical Sciences and Community Health “UniversitĂ degli Studi di Milano”, Milan, Italy | ||||
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