Evaluation of candidate vaccine approaches for MERS-CoV

NATURE COMMUNICATIONS | ARTICLE OPEN

• Lingshu Wang,
• Wei Shi,
• M. Gordon Joyce,
• Kayvon Modjarrad,
• Yi Zhang,
• Kwanyee Leung,
• Christopher R. Lees,
• Tongqing Zhou,
• Hadi M. Yassine,
• Masaru Kanekiyo,
• Zhi-yong Yang,
• Xuejun Chen,
• Michelle M. Becker,
• Megan Freeman,
• Leatrice Vogel,
• Joshua C. Johnson,
• Gene Olinger,
• John P. Todd,
• Ulas Bagci,
• Jeffrey Solomon
• et al.

Nature Communications

 

6,

 

Article number:

 

7712

 

doi:10.1038/ncomms8712

Received

 

21 April 2015 

Accepted

 

03 June 2015 

Published

 

28 July 2015

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Abstract

• Abstract• 
• Introduction• 
• Results• 
• Discussion• 
• Methods• 
• Additional information• 
• Accession codes•
• References• 
• Acknowledgements• 
• Author information• 
• Supplementary information

The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) as a cause of severe respiratory disease highlights the need for effective approaches to CoV vaccine development. Efforts focused solely on the receptor-binding domain (RBD) of the viral Spike (S) glycoprotein may not optimize neutralizing antibody (NAb) responses.

Cytokine profiles in nasal fluid of patients with seasonal or persistent allergic rhinitis

Research

Katrin König¹, Christine Klemens¹, Katharina Eder¹, Marion San Nicoló¹, Sven Becker¹², Matthias F. Kramer¹ andMoritz Gröger^1*

Allergy, Asthma & Clinical Immunology 2015, 11:26  doi:10.1186/s13223-015-0093-x

Abstract

Background

New therapeutic approaches with biologic agents such as anti-cytokine antibodies are currently on trial for the treatment of asthma, rhinosinusitis or allergic diseases necessitating patient selection by biomarkers. Allergic rhinitis (AR), affecting about 20 % of the Canadian population, is an inflammatory disease characterised by a disequilibrium of T-lymphocytes and tissue eosinophilia.

Atopic dermatitis: A cross-sectional (descriptive) study of 100 cases

E-IJD ORIGINAL ARTICLE

Year : 2015  |  Volume : 60  |  Issue : 5  |  Page : 519

Virendra N Sehgal1, Govind Srivastava2, Ashok K Aggarwal2, Deepti Saxena2, Kingshuk Chatterjee3, Ananta Khurana4 1 Dermato Venereology (Skin/VD) Center, Sehgal Nursing Home, Panchwati, Delhi, India 2 Skin Institute, School of Dermatology, Greater Kailash, New Delhi, India 3 Department of Dermatology, Bankura Sammilani Medical College, Bankura, West Bengal, India 4 Department of Dermatology, Dr RML hospital and Postgraduate Institute of Medical Education and research (PGIMER), New Delhi, India

Abstract   Background: Atopic dermatitis is a distinct age-related clinical entity. Its etiopathogenesis is largely insubstantial. Nevertheless, it seems to be an outcome of interplay of maternal and inheritance, pregnancy/intrauterine and environmental factors. Besides, immune dysregulation, and nutritional supplements also play essential roles. Its diagnosis has been perpetuated by three or more major/minor criteria.

Sublingual grass and ragweed immunotherapy: Clinical considerations—a PRACTALL consensus report

James T. Li, MD, PhD

,

 David I. Bernstein, MD

,

 Moises A. Calderon, MD, PhD

,

 Thomas B. Casale, MD

,

Linda Cox, MD

,

 Giovanni Passalacqua, MD

,

 Oliver Pfaar, MD

,

 Nikolaos G. Papadopoulos, MD

Received: May 18, 2015; Received in revised form: June 25, 2015; Accepted: June 30, 2015; Published Online:September 11, 2015

Publication stage: In Press Corrected Proof

DOI: http://dx.doi.org/10.1016/j.jaci.2015.06.046

   Article Info

• Abstract
• Full Text
• References

Sublingual allergen immunotherapy provides a new option for patients with allergic rhinitis in the United States. The efficacy of these sublingual immunotherapy tablets in the treatment of allergic rhinitis has been firmly established in large multicenter clinical trials. In addition, the clinical benefits of sublingual immunotherapy might persist after treatment is discontinued.

Airways resistance and specific conductance for the diagnosis of obstructive airways diseases

Research

Marko Topalovic¹, Eric Derom², Christian R. Osadnik³⁴⁵⁶, Thierry Troosters¹³, Marc Decramer¹, Wim Janssens^1* andon behalf of the Belgian Pulmonary Function Study Investigators

Respiratory Research 2015, 16:88  doi:10.1186/s12931-015-0252-0

Abstract

Background

Airway resistance (R _AW ) and specific airway conductance (sG _AW ) are measures that reflect the patency of airways. Little is known of the variability of these measures between different lung diseases. This study investigated the contribution of R _AW and sG _AW to a diagnosis of obstructive airways disease and their role in differentiating asthma from COPD.

The GINA asthma strategy report: what’s new for primary care?

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Abstract

NPJ Prim Care Respir Med. 2015; 25: 15050.

Helen K Reddel^1,* and Mark L Levy^2,3, on behalf of the Global Initiative for Asthma Scientific Committee and Dissemination and Implementation Committee

Author information ► Article notes ► Copyright and License information ►

Abstract

The Global Initiative for Asthma (GINA) was established in 1993 by the World Health Organization and National Heart Lung and Blood Institute to develop a global strategy for managing and preventing asthma. GINA reports, now funded independently through the sale of GINA products, have provided the foundation for many national guidelines. They are prepared by international experts from primary, secondary and tertiary care, and are annually updated following a review of evidence.

Interrelatedness between dysbiosis in the gut microbiota due to immunodeficiency and disease penetrance of colitis

• 
  
 

• Avijit Ray,

 
 
Summary
The composition of the microbiome in health and disease has only recently become a major research focus. Although it is clear that an imbalance or dysbiosis in the microbiota is associated with disease, its interrelatedness to disease penetrance is largely unknown.
Inflammatory bowel disease (IBD) is an excellent disease in which to explore these questions because of the extensive genetic studies identifying disease susceptibility loci and the ability to easily sample the intestinal microbiota in IBD patients due to the accessibility of stool samples. In addition, mouse models of IBD have contributed to our understanding of the interrelatedness of the gut microbiota and genes associated with IBD.

High risk for obstructive sleep apnea and other sleep disorders among overweight and obese pregnant women

Research article

Jayne R. Rice¹, Gloria T. Larrabure-Torrealva²³, Miguel Angel Luque Fernandez¹, Mirtha Grande⁵, Vicky Motta², Yasmin V. Barrios¹, Sixto Sanchez⁴⁵, Bizu Gelaye^1* and Michelle A. Williams¹

BMC Pregnancy and Childbirth 2015, 15:198  doi:10.1186/s12884-015-0633-x

Abstract

Background

Obstructive sleep apnea (OSA), a common and serious disorder in which breathing repeatedly stops during sleep, is associated with excess weight and obesity. Little is known about the co-occurrence of OSA among pregnant women from low and middle-income countries.