Combination of specific allergen and probiotics induces specific regulatory B cells and enhances specific immunotherapy effect on allergic rhinitis

DOI: 10.18632/oncotarget.10946

Ling-Zhi Xu1,*, Li-Tao Yang1,2,*, Shu-Qi Qiu1,2,*, Gui Yang1,2, Xiang-Qian Luo3, Bei-Ping Miao4, Xiao-Rui Geng1,2, Zhi-Qiang Liu1,2, Jun Liu5, Zhong Wen6, Shuai Wang1,2, Huan-Ping Zhang7, Jing Li8, Zhi-Gang Liu1, Hua-Bin Li3 and Ping-Chang Yang1

DOI: 10.18632/oncotarget.10946

ABSTRACT

The therapeutic efficacy of allergen specific immunotherapy (SIT) on allergic diseases is to be improved. Probiotics can regulate immune response. This study aims to promote the effect of SIT on allergic rhinitis (AR) by co-administration with Clostridium butyricum(Cb). In this study, patients with AR sensitized to mite allergens were enrolled to this study, and treated with SIT or/and Cb. The therapeutic efficacy was evaluated by the total nasal symptom scores (NSS), medication scores, serum specific IgE levels and T helper (Th)2 cytokine levels. The improvement of immune regulation in the AR patients was assessed by immunologic approaches.

Defects of corneocyte structural proteins and epidermal barrier in atopic dermatitis

Volume 396, Issue 11 (Nov 2015)

FREE ACCESS

Marina Le Lamer1 / Laurence Pellerin1, a / Marie Reynier1 / Laura Cau1 / Valérie Pendaries1, b / Corinne Leprince1 / Marie-Claire Méchin1 / Guy Serre1 / Carle Paul1, 2 / Michel Simon3

Abstract

The main function of the epidermis is to establish a vital multifunctional barrier between the body and its external environment. A defective epidermal barrier is one of the key features of atopic dermatitis (AD), a chronic and relapsing inflammatory skin disorder that affects up to 20% of children and 2–3% of adults and often precedes the development of allergic rhinitis and asthma.

Behavioral interventions to reduce inappropriate antibiotic prescribing: a randomized pilot trial

RESEARCH ARTICLE

 

OPEN ACCESS

 

OPEN PEER REVIEW

• Stephen D. PersellEmail author,
• Jason N. Doctor,
• Mark W. Friedberg,
• Daniella Meeker,
• Elisha Friesema,
• Andrew Cooper,
• Ajay Haryani,
• Dyanna L. Gregory,
• Craig R. Fox,
• Noah J. Goldstein and
• Jeffrey A. Linder

BMC Infectious DiseasesBMC series – open, inclusive and trusted201616:373

DOI: 10.1186/s12879-016-1715-8

©  The Author(s). 2016

Open Peer Review reports

Abstract

Background

Clinicians frequently prescribe antibiotics inappropriately for acute respiratory infections (ARIs). Our objective was to test information technology-enabled behavioral interventions to reduce inappropriate antibiotic prescribing for ARIs in a randomized controlled pilot test trial.

Climate Change and Air Pollution: Effects on Respiratory Allergy

Review
	Allergy Asthma Immunol Res. 2016 Sep;8(5):391-395.  Gennaro D'Amato,1,2 Ruby Pawankar,3 Carolina Vitale,4 Maurizia Lanza,4 Antonio Molino,4 Anna Stanziola,4 Alessandro Sanduzzi,2,5 Alessandro Vatrella,6 and Maria D'Amato4 1Division of Respiratory and Allergic Diseases, Department of Chest Diseases High Speciality, A. Cardarelli Hospital, Napoli, Italy. 2University "Federico II", Medical School, Naples, Italy. 3Division of Allergy, Department of Pediatrics, Nippon Medical School, Tokyo, Japan. 4First Division of Pneumology, High Speciality Hospital "V. Monaldi" and University "Federico II" Medical School, Naples, Italy. 5Second Division of Pneumology, High Speciality Hospital "V. Monaldi" and University "Federico II" Medical School, Naples, Italy. 6Department of Medicine and Surgery, University of Salerno, Salerno, Italy. Abstract A body of evidence suggests that major changes involving the atmosphere and the climate, including global warming induced by anthropogenic factors, have impact on the biosphere and human environment. Studies on the effects of climate change on respiratory allergy are still lacking and current knowledge is provided by epidemiological and experimental studies on the relationship between allergic respiratory diseases, asthma and environmental factors, such as meteorological variables, airborne allergens, and air pollution.

Identification of novel macrolides with antibacterial, anti-inflammatory and type I and III IFN-augmenting activity in airway epithelium

J. Antimicrob. Chemother. (2016)doi: 10.1093/jac/dkw222

James D. Porter1,2, 

Jennifer Watson1, 

Lee R. Roberts3, 

Simren K. Gill4, 

Helen Groves4,

Jaideep Dhariwal1,2, 

Mark H. Almond1,2, 

Ernie Wong1,2, 

Ross P. Walton1,2, 

Lyn H. Jones3, 

John Tregoning4, 

Iain Kilty3, 

Sebastian L. Johnston1,2 and 

Michael R. Edwards1,2,*

Author Affiliations

1. ¹Airway Disease Infection Section, National Heart Lung Institute, Imperial College London, London, UK
2. ²MRC & Asthma UK Centre for Allergic Mechanisms of Asthma, London, UK
3. ³Pfizer Inc., Cambridge, MA, USA
4. ⁴Mucosal Infection and Immunity Group, Section of Virology, Imperial College London, London, UK

 

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Abstract

Background Exacerbations of asthma and COPD are triggered by rhinoviruses. Uncontrolled inflammatory pathways, pathogenic bacterial burden and impaired antiviral immunity are thought to be important factors in disease severity and duration. Macrolides including azithromycin are often used to treat the above diseases, but exhibit variable levels of efficacy. Inhaled corticosteroids are also readily used in treatment, but may lack specificity. Ideally, new treatment alternatives should suppress unwanted inflammation, but spare beneficial antiviral immunity.

Value of peripheral blood eosinophil markers to predict severity of asthma

• Julian Casciano,
• Jerry A. Krishnan,
• Mary Buatti Small,
• Philip O. Buck,
• Gokul Gopalan,
• Chenghui Li,
• Robert Kemp and
• Zenobia DotiwalaEmail author

BMC Pulmonary MedicineBMC series – open, inclusive and trusted201616:109

DOI: 10.1186/s12890-016-0271-8

Open Peer Review reports

Abstract

Background

Asthma represents a significant clinical and economic burden to the US healthcare system. Along with other clinical manifestations of the disease, elevated sputum and blood eosinophil levels are observed in patients experiencing asthma exacerbations. The aim of this study was to evaluate the association between blood eosinophil levels and asthma severity defined using Expert Panel Report 3 guidelines.

Dr. Linda Cox reviews the latest information regarding sublingual allergen immunotherapy (SLIT)

ACAAICOLA

Management of rhinosinusitis during pregnancy: systematic review and expert panel recommendations

Volume: 54 - Issue: 2, pp99-104, 2016
D. Lal - A.A. Jategaonkar - L. Borish - L.R. Chambliss - S.H. Gnagi - P.H. Hwang - M.A. Rank - J.A. Stankiewicz - V.J. Lund

BACKGROUND: Management of rhinosinusitis during pregnancy requires special considerations.
OBJECTIVES: 1. Conduct a systematic literature review for acute and chronic rhinosinusitis (CRS) management during pregnancy. 2. Make evidence-based recommendations.
METHODS: The systematic review was conducted using MEDLINE and EMBASE databases and relevant search terms. Title, abstract and full manuscript review were conducted by two authors independently. A multispecialty panel with expertise in management of Rhinological disorders, Allergy-Immunology, and Obstetrics-Gynecology was invited to review the systematic review. Recommendations were sought on use of following for CRS management during pregnancy: oral corticosteroids; antibiotics; leukotrienes; topical corticosteroid spray/irrigations/drops; aspirin desensitization; elective surgery for CRS with polyps prior to planned pregnancy; vaginal birth versus planned Caesarian for skull base erosions/ prior CSF rhinorrhea.