Breakthrough attacks in patients with hereditary angioedema receiving long-term prophylaxis are responsive to icatibant: findings from the Icatibant Outcome Survey

Allergy, Asthma & Clinical Immunology

RESEARCH

 

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• Werner AbererEmail author,
• Marcus Maurer,
• Laurence Bouillet,
• Andrea Zanichelli,
• Teresa Caballero,
• Hilary J. Longhurst,
• Amandine Perrin,
• Irmgard Andresen and
• for the IOS Study Group

Allergy, Asthma & Clinical Immunology201713:31

DOI: 10.1186/s13223-017-0203-z

Abstract

Background

Patients with hereditary angioedema (HAE) due to C1-inhibitor deficiency (C1-INH-HAE) experience recurrent attacks of cutaneous or submucosal edema that may be frequent and severe; prophylactic treatments can be prescribed to prevent attacks. However, despite the use of long-term prophylaxis (LTP), breakthrough attacks are known to occur. We used data from the Icatibant Outcome Survey (IOS) to evaluate the characteristics of breakthrough attacks and the effectiveness of icatibant as a treatment option.

Azithromycin for idiopathic acute exacerbation of idiopathic pulmonary fibrosis: a retrospective single-center study

BMC Pulmonary Medicine

RESEARCH ARTICLE

 

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• Kodai KawamuraEmail author,
• Kazuya Ichikado,
• Yuko Yasuda,
• Keisuke Anan and
• Moritaka Suga

BMC Pulmonary MedicineBMC series – open, inclusive and trusted201717:94

DOI: 10.1186/s12890-017-0437-z

Abstract

Background

Acute exacerbation (AE) of idiopathic pulmonary fibrosis (IPF) is a fatal condition without an established pharmaceutical treatment. Most patients are treated with high-dose corticosteroids and broad-spectrum antibiotics. Azithromycin is a macrolide with immunomodulatory activity and may be beneficial for treatment of acute lung injury. The objective of this study was to determine the effect of azithromycin on survival of patients with idiopathic AE of IPF.

Novel aspects in diagnostic approach to respiratory patients: is it the time for a new semiotics?

Multidisciplinary Respiratory Medicine

STATE OF THE ART

 

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• Gino Soldati,
• Andrea SmargiassiEmail author,
• Alberto A. Mariani and
• Riccardo Inchingolo

Multidisciplinary Respiratory Medicine201712:15

DOI: 10.1186/s40248-017-0098-z

Abstract

Medical approach to patients is a fundamental step to get the correct diagnosis. The aim of this paper is to analyze some aspects of the reasoning process inherent in medical diagnosis in our era. Pathologic signs (anamnestic data, symptoms, semiotics, laboratory and strumental findings) represent informative phenomena to be integrated for inferring a diagnosis. Thus, diagnosis begins with “signs” and finishes in a probability of disease.

Asthma pressurised metered dose inhaler performance: propellant effect studies in delivery systems

Allergy, Asthma & Clinical Immunology

RESEARCH

 

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• William F. S. SellersEmail author

Allergy, Asthma & Clinical Immunology201713:30

DOI: 10.1186/s13223-017-0202-0

Abstract

Background

Current pressurised metered dose asthma inhaler (pMDI) propellants are not inert pharmacologically as were previous chlorofluorocarbons, have smooth muscle relaxant‚ partial pressure effects in the lungs and inhaled hydrofluoroalkane 134a (norflurane) has anaesthetic effects. Volumes of propellant gas per actuation have never been measured.

Trust and Credibility in Web-Based Health Information: A Review and Agenda for Future Research

Journal of Medical Internet Research

Original Paper

Laura Sbaffi^1*, MA, PhD ; 

Jennifer Rowley^2*, MSc, PhD 

ABSTRACT

Background: Internet sources are becoming increasingly important in seeking health information, such that they may have a significant effect on health care decisions and outcomes. Hence, given the wide range of different sources of Web-based health information (WHI) from different organizations and individuals, it is important to understand how information seekers evaluate and select the sources that they use, and more specifically, how they assess their credibility and trustworthiness.

Angioedema suppressed by a combination of anti-histamine and leukotriene modifier

SHORT REPORT

 

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• Brendan N. Wong and
• Peter VadasEmail author

Allergy, Asthma & Clinical Immunology201713:28

DOI: 10.1186/s13223-017-0201-1

Abstract

Rationale

Angioedema without co-existent urticaria is due to a limited number of causes, including hereditary and acquired C1 esterase inhibitor deficiency, drug-induced angioedema or idiopathic histaminergic or non-histaminergic angioedema. We describe a cohort of patients with recurrent angioedema whose clinical features and response to medications are distinct from the causes above.

Computational analysis of multimorbidity between asthma, eczema and rhinitis

OPEN ACCESS    PEER-REVIEWED

RESEARCH ARTICLE

Daniel Aguilar ,Mariona Pinart,Gerard H. Koppelman,Yvan Saeys,Martijn C. Nawijn,Dirkje S. Postma,Mübeccel Akdis,Charles Auffray,Stéphane Ballereau,Marta Benet,Judith García-Aymerich,Juan Ramón González,Stefano Guerra, Josep M. Antó

https://doi.org/10.1371/journal.pone.0179125

Abstract

Background

The mechanisms explaining the co-existence of asthma, eczema and rhinitis (allergic multimorbidity) are largely unknown. We investigated the mechanisms underlying multimorbidity between three main allergic diseases at a molecular level by identifying the proteins and cellular processes that are common to them.

Comparison of the Performance of Skin Prick, ImmunoCAP, and ISAC Tests in the Diagnosis of Patients with Allergy

Molecules and Cells in Allergy - Original Paper

Editor's Choice -- Free Access

	Griffiths R.L.M. · El-Shanawany T. · Jolles S.R.A. · Selwood C. · Heaps A.G. · Carne E.M. · Williams P.E.  Int Arch Allergy Immunol 2017;172:215-223 https://doi.org/10.1159/000464326 Author affiliations Corresponding Author

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Background: Allergy is diagnosed from typical symptoms, and tests are performed to incriminate the suspected precipitant. Skin prick tests (SPTs) are commonly performed, inexpensive, and give immediate results. Laboratory tests (ImmunoCAP) for serum allergen-specific IgE antibodies are usually performed more selectively.