Respiratory effect of beta-blockers in people with asthma and cardiovascular disease: population-based nested case control study

Research article

Open Access

Open Peer Review

• Daniel R. MoralesEmail author,
• Brian J. Lipworth,
• Peter T. Donnan,
• Cathy Jackson and
• Bruce Guthrie

BMC Medicine201715:18

https://doi.org/10.1186/s12916-017-0781-0

Open Peer Review reports

Abstract

Background

Cardiovascular disease (CVD) is a common comorbidity in people with asthma. However, safety concerns have caused heterogeneity in clinical guideline recommendations over the use of cardioselective beta-blockers in people with asthma and CVD, partly because risk in the general population has been poorly quantified.

Physiotherapy breathing retraining for asthma: a randomised controlled trial

Prof Anne Bruton, PhD, Prof Amanda Lee, PhD, Prof Lucy Yardley, PhD, Prof James Raftery, PhD, Emily Arden-Close, PhD, Sarah Kirby, PhD, Shihua Zhu, PhD, Manimekalai Thiruvothiyur, MSc, Frances Webley, Lyn Taylor, Denise Gibson, MSc, Guiqing Yao, PhD, Mark Stafford-Watson, Jenny Versnel, PhD, Prof Michael Moore, FRCGP, Steve George, FRCGP, Prof Paul Little, FMedSci, Prof Ratko Djukanovic, PhD, Prof David Price, FRCGP, Prof Ian D Pavord, FMedSci, Prof Stephen T Holgate, FMedSci, Prof Mike Thomas, PhD

Correspondence information about the author Prof Mike ThomasEmail the author Prof Mike Thomas

Published: 13 December 2017

Open Access

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DOI: http://dx.doi.org/10.1016/S2213-2600(17)30474-5

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Article Info

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• References
 
• Supplementary Material

Summary

Background

Despite effective pharmacotherapy, asthma continues to impair quality of life for most patients. Non-pharmacological approaches, including breathing retraining, are therefore of great interest to patients.

A pilot study with early adolescents: dealing with diet, tobacco and air pollution using practical experiences and biological markers

Short Report

Open Access

• Chiara Marabelli,
• Elena MunariniEmail authorView ORCID ID profile,
• Micaela Lina,
• Roberto Mazza,
• Roberto Boffi,
• Cinzia De Marco,
• Ario Ruprecht,
• Giorgia Angellotti,
• Chiara Veronese,
• Paolo Pozzi,
• Eleonora Bruno,
• Giuliana Gargano,
• Adalberto Cavalleri,
• Giulia Garrone and
• Franco Berrino

Multidisciplinary Respiratory Medicine201712:30

https://doi.org/10.1186/s40248-017-0111-6

Abstract

Background: Tobacco use and the Western diet are two of the most important and investigated topics in relation to adolescents’ health. In addition, air pollution is a crucial subject for future generations. School is a key social environment that should promote healthy behaviors in children and adolescents. In this field many different programs have been conducted, with mixed results and effectiveness. Research data suggest that comprehensive and multicomponent approaches may have a greater effect on tobacco use and diet, especially when integrated into a community-wide approach.

Adverse drug reactions of montelukast in children and adults

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Volume 5, Issue 5
October 2017
e00341

• Open Access
• Creative Commons

Original Article

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• First published: 20 September 2017Full publication history
• DOI: 10.1002/prp2.341  View/save citation
• Cited by (CrossRef): 0 articlesCheck for updates
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• Principal Investigator: Tjalling W de Vries MD PhD

Abstract

Montelukast, a selective leukotriene receptor antagonist, is recommended in guidelines for the treatment of asthma in both children and adults. However, its effectiveness is debated, and recent studies have reported several adverse events such as neuropsychiatric disorders and allergic granulomatous angiitis.

Novel therapeutic approaches to simultaneously target rhinovirus infection and asthma/COPD pathogenesis

Mirabelli C, Scheers E and Neyts J. Novel therapeutic approaches to simultaneously target rhinovirus infection and asthma/COPD pathogenesis [version 1; referees: 2 approved]. F1000Research 2017, 6(F1000 Faculty Rev):1860 (doi: 10.12688/f1000research.11978.1)

Abstract

Rhinoviruses are exclusive respiratory pathogens and the etiological agents of the common cold. These viruses are increasingly reported to cause exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Here, we review the role of rhinovirus infections in the pathogenesis of asthma and COPD and we discuss the current and potential future treatments. We propose that, in order to prevent exacerbations, the design of novel therapeutics should focus on directly acting antivirals but also include the design of drugs that simultaneously inhibit viral replication and alleviate symptoms of asthma and COPD.

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Virus-triggered exacerbation in allergic asthmatic children: neutrophilic airway inflammation and alteration of virus sensors characterize a subgroup of patients

RESEARCH

 

OPEN ACCESS

• Antoine DeschildreEmail author,
• Muriel Pichavant,
• Ilka Engelmann,
• Carole Langlois,
• Elodie Drumez,
• Guillaume Pouessel,
• Sophie Boileau,
• David Romero-Cubero,
• Irina Decleyre-Badiu,
• Anny Dewilde,
• Didier Hober,
• Véronique Néve,
• Caroline Thumerelle,
• Stéphanie Lejeune,
• Clémence Mordacq and
• Philippe GossetEmail authorView ORCID ID profile

Respiratory Research201718:191

https://doi.org/10.1186/s12931-017-0672-0

©  The Author(s). 2017

Abstract

Background

Viruses are important triggers of asthma exacerbations. They are also detected outside of exacerbation. Alteration of anti-viral response in asthmatic patients has been shown although the mechanisms responsible for this defect remain unclear. The objective of this study was to compare in virus-infected and not-infected allergic asthmatic children, aged 6 to 16 years, admitted to hospital for a severe exacerbation, the innate immune response and especially the expression of pattern recognition receptor (PRR) and their function.